Stapled truncated orexin peptides as orexin receptor agonists
نویسندگان
چکیده
منابع مشابه
Stapled truncated orexin peptides as orexin receptor agonists
The peptides orexin-A and -B, the endogenous agonists of the orexin receptors, have similar 19-amino-acid C-termini which retain full maximum response as truncated peptides with only marginally reduced potency, while further N-terminal truncations successively reduce the activity. The peptides have been suggested to bind in an α-helical conformation, and truncation beyond a certain critical len...
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ژورنال
عنوان ژورنال: Peptides
سال: 2018
ISSN: 0196-9781
DOI: 10.1016/j.peptides.2018.02.004